Question 1

All of the following may result in an acquired immunodeficiency EXCEPT:

Accepted Answer

A)  Malnutrition
B)  Treatment with corticosteroids
C)  Disseminated cancer
D)  Inherited defect in B cell maturation
E)  Infection with human immunodeficiency virus (HIV) F) All of the above
G) B) and E)

Question 2

Match each of the following descriptions in questions with the appropriate disease (A-G) .
-Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk) ,resulting in undetectable levels of serum Ig

Accepted Answer

A)  X-linked agammaglobulinemia
B)  X-linked hyper-IgM syndrome
C)  X-linked lymphoproliferative syndrome
D)  Class II MHC deficiency
E)  Chronic granulomatous disease (CG
D)  F) Leukocyte adhesion deficiency-1 (LAD-1) G) Leukocyte adhesion deficiency-2 (LAD-2) H) A) and F)
I) D) and F) A

Question 3

Match each of the following descriptions in questions with the appropriate disease (A-G) .
-Defect in phagocyte microbicidal activity as a result of defective production of reactive oxygen intermediates,most commonly from a mutation in the gene encoding cytochrome b558

Accepted Answer

A)  X-linked agammaglobulinemia
B)  X-linked hyper-IgM syndrome
C)  X-linked lymphoproliferative syndrome
D)  Class II MHC deficiency
E)  Chronic granulomatous disease (CG
D)  F) Leukocyte adhesion deficiency-1 (LAD-1) G) Leukocyte adhesion deficiency-2 (LAD-2) H) A) and E)
I) All of the above E

Question 4

Which molecules on the T cell surface are directly involved in HIV infection?

Accepted Answer

A)  CD4 and CD25
B)  CCR5 and CD25
C)  CD3 and CD4
D)  CD8 and CCR5
E)  CD4 and CCR5F) B) and C)
G) A) and E)

Question 5

Match each of the following descriptions in questions with the appropriate disease (A-G) .
-Defect in lymphocyte activation due to mutations in the gene encoding the SAP adapter protein required for inhibition of signaling by the SLAM molecule.Lack of SAP results in uncontrolled B cell proliferation,hypogammaglobulinemia,and B cell lymphoma in the setting of Epstein-Barr virus (EBV) infection.

Accepted Answer

A)  X-linked agammaglobulinemia
B)  X-linked hyper-IgM syndrome
C)  X-linked lymphoproliferative syndrome
D)  Class II MHC deficiency
E)  Chronic granulomatous disease (CG
D)  F) Leukocyte adhesion deficiency-1 (LAD-1) G) Leukocyte adhesion deficiency-2 (LAD-2) H) A) and E)
I) C) and F) C

Question 6

Match each of the following descriptions in questions with the appropriate disease (A-G) .
-Impaired CD4+ T cell development and activation,resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity
H.

Accepted Answer

A)  X-linked agammaglobulinemia
B)  X-linked hyper-IgM syndrome
C)  X-linked lymphoproliferative syndrome
D)  Class II MHC deficiency
E)  Chronic granulomatous disease (CG
D)  F) Leukocyte adhesion deficiency-1 (LAD-1) G) Leukocyte adhesion deficiency-2 (LAD-2) H) A) and C)
I) D) and E)

Question 7

In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH) response to a Candida antigen skin challenge?

Accepted Answer

A)  X-linked agammaglobulinemia
B)  DiGeorge syndrome
C)  Selective IgA deficiency
D)  Common variable immunodeficiency
E)  Chronic granulomatous diseaseF) B) and D)
G) A) and B)

Question 8

A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses,as described in question 3,is called:

Accepted Answer

A)  Clinical atopy
B)  Clonal ignorance
C)  Clinical anergy
D)  Clonal deletion
E)  SeroconversionF) A) and B)
G) All of the above

Question 9

Which one of the following is typically NOT associated with T cell immunodeficiencies?

Accepted Answer

A)  Cancer
B)  Viral infection
C)  Autoimmunity
D)  Infection with intracellular microbes
E)  Infection with pyogenic bacteriaF) B) and E)
G) B) and D)

Question 10

The progression of HIV infection to AIDS is most directly due to which of the following?

Accepted Answer

A)  A loss of CD4+ T cells to numbers insufficient to prevent infections
B)  Reduction in serum IgG levels to levels insufficient to prevent infections
C)  Increased amount of virus in the blood
D)  Loss of weight
E)  Reduction in CD8+ CTLs specific for HIVF) A) and E)
G) A) and D)

Question 11

Match each of the following descriptions in questions with the appropriate disease (A-G) .
-Defect in leukocyte adhesion-dependent functions,resulting from mutations in the gene encoding the CD18 integrin β chain,and leading to recurrent bacterial and fungal infections

Accepted Answer

A)  X-linked agammaglobulinemia
B)  X-linked hyper-IgM syndrome
C)  X-linked lymphoproliferative syndrome
D)  Class II MHC deficiency
E)  Chronic granulomatous disease (CG
D)  F) Leukocyte adhesion deficiency-1 (LAD-1) G) Leukocyte adhesion deficiency-2 (LAD-2) H) All of the above
I) B) and E)

Question 12

Which of the following is not a valid explanation for why patients cannot eradicate HIV infections?

Accepted Answer

A)  HIV does not stimulate a CD8+ CTL response.
B)  HIV mutation rate is high,leading to evasion of immune recognition.
C)  A reservoir of latently infected cells invisible to the immune system is established rapidly after infection.
D)  CD4+ T cells are destroyed,impairing the immune response to the virus.E) C) and D)
F) A) and B)

Exam 8: Immunodeficiency-Diseases

All of the following may result in an acquired immunodeficiency EXCEPT:

Correct Answer
verified

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk) ,resulting in undetectable levels of serum Ig

Correct Answer
verified
A

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in phagocyte microbicidal activity as a result of defective production of reactive oxygen intermediates,most commonly from a mutation in the gene encoding cytochrome b558

Correct Answer
verified
E

Which molecules on the T cell surface are directly involved in HIV infection?

Correct Answer
verified

Correct Answer
verified
C

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Impaired CD4+ T cell development and activation,resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity H.

Correct Answer
verified

In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH) response to a Candida antigen skin challenge?

Correct Answer
verified

A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses,as described in question 3,is called:

Correct Answer
verified

Which one of the following is typically NOT associated with T cell immunodeficiencies?

Correct Answer
verified

The progression of HIV infection to AIDS is most directly due to which of the following?

Correct Answer
verified

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in leukocyte adhesion-dependent functions,resulting from mutations in the gene encoding the CD18 integrin β chain,and leading to recurrent bacterial and fungal infections

Correct Answer
verified

Which of the following is not a valid explanation for why patients cannot eradicate HIV infections?

Correct Answer
verified

Exam 8: Immunodeficiency-Diseases

All of the following may result in an acquired immunodeficiency EXCEPT:

Correct AnswerverifiedShow Answer

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk) ,resulting in undetectable levels of serum Ig

Correct AnswerverifiedA

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in phagocyte microbicidal activity as a result of defective production of reactive oxygen intermediates,most commonly from a mutation in the gene encoding cytochrome b558

Correct AnswerverifiedE

Which molecules on the T cell surface are directly involved in HIV infection?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedC

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Impaired CD4+ T cell development and activation,resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity H.

Correct AnswerverifiedShow Answer

In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH) response to a Candida antigen skin challenge?

Correct AnswerverifiedShow Answer

A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses,as described in question 3,is called:

Correct AnswerverifiedShow Answer

Which one of the following is typically NOT associated with T cell immunodeficiencies?

Correct AnswerverifiedShow Answer

The progression of HIV infection to AIDS is most directly due to which of the following?

Correct AnswerverifiedShow Answer

Match each of the following descriptions in questions with the appropriate disease (A-G) . -Defect in leukocyte adhesion-dependent functions,resulting from mutations in the gene encoding the CD18 integrin β chain,and leading to recurrent bacterial and fungal infections

Correct AnswerverifiedShow Answer

Which of the following is not a valid explanation for why patients cannot eradicate HIV infections?

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified
A

Correct Answer
verified
E

Correct Answer
verified

Correct Answer
verified
C

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified