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Which of the following is expected to decrease as the HIV infection progresses into AIDS?


A) WBC count
B) CD4:CD8 ratio
C) Lymphocyte count
D) All of the above

E) A) and B)
F) None of the above

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The Epstein-Barr virus targets B cells that express _______.Once infected, they cause expression of the_______ marker.


A) CD21; CD23
B) CD23; CD21
C) CD22; CD23
D) CD34; CD19

E) A) and B)
F) A) and C)

Correct Answer

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What component is responsible for the accumulation of lymphocytes in the blood during a whooping cough infection?


A) Pertussis toxin
B) Leukemoid reaction
C) T lymphocytes
D) VCA-IgG

E) C) and D)
F) B) and C)

Correct Answer

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A 42-year-old HIV-positive patient recently was diagnosed with disseminated histoplasmosis.Which of the following should be ordered to monitor this patient's progression?


A) HIV antibody screen
B) HBsAg
C) CBC
D) CD4:CD8 ratio

E) B) and D)
F) B) and C)

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A 5-year-old girl has a WBC count of 11 x 109/L with 55% lymphocytes.Which of the following best describes this phenomenon?


A) Absolute lymphocytosis
B) Relative lymphocytosis
C) Normal leukocyte count
D) Absolute lymphocytopenia

E) A) and B)
F) A) and C)

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The prominent lymphocytosis in whooping cough is due to:


A) An exacerbated immune response.
B) Cell-mediated immunity accompanying a neutrophilia.
C) Redistribution of lymphocytes from the lymphatics into peripheral circulation.
D) Increased cytokine stimulation of lymphopoiesis in the bone marrow.

E) B) and D)
F) A) and B)

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A negative heterophile antibody test in a patient with symptoms of infectious mononucleosis could be due to what factor if the patient is being treated for cancer?


A) Infection by another virus
B) The level of the antibody is not high enough to be detected.
C) Immunosuppressed antibody response
D) CMV infection

E) B) and D)
F) B) and C)

Correct Answer

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Which of the following statements best describes the pathogenesis of HIV infection?


A) HIV virus selectively infects T helper cells, incorporates its own DNA into the DNA of the T helper, and lyses the cell.
B) HIV virus infects all lymphocytes, incorporates its own DNA into the DNA of the T helper, and changes the identity of the T helper.
C) HIV virus infects all cells involved in cell-mediated immunity, incorporates its own DNA into the DNA of the infected cells, and lyses the cells.
D) HIV infects T-suppressor cells and initiates apoptosis.

E) B) and D)
F) A) and B)

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CMV infections complicate transplants by which of the following mechanisms?


A) Formation of antibodies to CMV infected cells which cross-react with stem cells
B) Suppress normal immune function and elicit the formation of autoantibodies that are lymphocytotoxic
C) Impair mitotic division of normal hematopoietic cells and stimulate neoplastic cells to proliferate
D) Stimulate antibodies against RBCs resulting in an autoimmune hemolytic anemia

E) B) and C)
F) All of the above

Correct Answer

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Which of the following cell types is commonly infected by the HIV-1 virus?


A) Cytotoxic T cells
B) CD8 cells
C) CD4 cells
D) Neutrophils

E) B) and D)
F) All of the above

Correct Answer

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A patient with infectious mononucleosis is having serologic blood tests.Results are as follows: EBVCA IgG: 1:320; EBVCA IgM: not detected; EBNA: 1:20.What stage of infection is the patient in?


A) Acute
B) Recent
C) Past
D) Cannot be determined

E) A) and C)
F) B) and C)

Correct Answer

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An 18-year old patient has a WBC count of 9 x 109/L and 60% lymphs, 30% neutrophils, 6% monocytes, 3% eosinophils and 1% basophils.The following best describes this condition:


A) Relative and absolute neutrophilia.
B) Absolute neutropenia and absolute lymphocytosis.
C) Relative neutropenia and absolute lymphocytosis.
D) Relative lymphocytopenia and relative neutropenia.

E) None of the above
F) All of the above

Correct Answer

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