Question 1

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

Accepted Answer

A)  Ubiquitin.
B)  Adaptin.
C)  Clathrin.
D)  Tubulin.
E)  Dolichol.F) A) and E)
G) B) and D) A

Question 2

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Accepted Answer

A)  N-acetylglucosamine.
B)  Glucose.
C)  Mannose.
D)  Iduronic acid.
E)  N-acetylneuraminic acid.F) A) and B)
G) None of the above E

Question 3

The most promising gene therapy strategy for I-cell disease is to:

Accepted Answer

A)  Introduce an intact copy of the a-L-iduronidase gene.
B)  Replace a normal copy of the iduronate sulfatase gene with one containing a nuclear localization signal.
C)  Replace the N-acetyl-galactosamine transferase gene with one containing a lysosomal localization signal.
D)  Replace a faulty copy of the mannose-6-phosphate transferase gene with a functional copy.
E)  Replace all lysosomal enzyme genes.F) A) and E)
G) C) and E) D

Question 4

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Accepted Answer

A)  Proteolytic removal of the first two or three amino acid residues from the amino terminus by the signal recognition particle.
B)  Attachment of a mannose-rich oligopeptide to asparagine side chains.
C)  Attachment of mannose-6-phosphate to the protein.
D)  Proteolytic cleavage by signal peptidase.
E)  Formation of disulfide bonds.F) D) and E)
G) C) and D)

Exam 8: Protein Targeting

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

Correct Answer
verified
A

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Correct Answer
verified
E

The most promising gene therapy strategy for I-cell disease is to:

Correct Answer
verified
D

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Correct Answer
verified

Exam 8: Protein Targeting

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

Correct AnswerverifiedA

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Correct AnswerverifiedE

The most promising gene therapy strategy for I-cell disease is to:

Correct AnswerverifiedD

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Correct AnswerverifiedShow Answer

Correct Answer
verified
A

Correct Answer
verified
E

Correct Answer
verified
D

Correct Answer
verified